This has really been a doosey! Thanks, Mr. Roberts. :) The symptoms of this issue is that all the usb ports on the Windows 10 computer do not work which prevent using the keyboard and mouse from working and logging into the computer. The keyboard and mouse do work, however, before Windows loads (ie BIOS settings screen).
The root cause of the problem is a recent Windows update (KB4074588). This was published mid-February 2018 and I'll focus the steps below for this specific problem. I'll cut out many of the troubleshooting steps I did and give you a targeted solution to speed up your recovery for this specific issue. I'll list the easy things to try first that may work then progress to other solutions. The ultimate goal for this problem is to remove KB4074588 and prevent it from re-installing by whatever means you can muster.
Try the easy things first:
- Use remote access to remove the update by the normal method (if remote access had been previously configured)
- Attempt to restore your pc to an earlier date when it was working properly
- Try booting into Safe Mode and removing the upgrade
- dism /Image:c:\ /remove-package /packagename:Package_for_RollupFix~31bf3856ad364e35~amd64~~162188.8.131.52